The week in bioRxiv

Improving access to endogenous DNA in ancient bone and teeth

Peter B. Damgaard, Ashot Margaryan, Hannes Schroeder, Ludovic Orlando, Eske Willerslev, Morten E. Allentoft
February 6, 2015; doi: http://dx.doi.org/10.1101/014985

Poor DNA preservation is the most limiting factor in ancient genomic research. In the vast majority of ancient bones and teeth, endogenous DNA molecules only represent a minor fraction of the whole DNA extract, rendering traditional shot-gun sequencing approaches cost-ineffective for whole-genome characterization.  … ⇒